2026 Revision

Engineering Human
Permanence.

PHASE_01In Progress

Foundational Infrastructure

The Hardware Layer

Timeline

24–36 Months (Q1 2026 – Q1 2029)

Establishing the biological baseline through high-fidelity synthesis.

Strategic Rationale

While Generative Bio-AI accelerates hit identification, the 'wet lab' validation of precision compounds and GMP facility setup remains a multi-year endeavor.

Key Milestones

1.1

Generative Synthesis & Purity

Deploy LLMs trained on protein sequences to design proprietary molecules (NAD+ variants, senolytics) with >99.5% purity.

1.2

Delivery Architecture

Standardize non-invasive Lipid Nanoparticle (LNP) delivery for high bioavailability and systemic 'Architecture for Continuity.'

1.3

OS v1.0 & Multi-Omic Ingestion

Launch the dashboard to ingest 'Deep Phenotype' data, including epigenetic clocks and metabolic flux.

1.4

CNPV Pilot Entry

Secure entry into the FDA Commissioner's National Priority Voucher program to compress future review times from 12 months to 1–2 months.

Target KPIs

100% molecular fidelity
80% user retention in initial 1,000-person beta cohort
PHASE_02

Predictive Integration

The Intelligence Layer

Timeline

36–60 Months Cumulative (2029 – 2031)

Activating the system to transition from reactive monitoring to proactive intervention.

Strategic Rationale

AI model development in healthspan takes ~2 years of longitudinal data collection from Phase 1 pilots and ethical AI validation.

Key Milestones

2.1

The Foresight Engine

Deploy ML models capable of forecasting 'Biological Lag' and biomarker decline 60 days before clinical onset.

2.2

Edge AI Monitoring

Transition to privacy-first, on-device diagnostic models that process physiological patterns locally rather than in the cloud.

2.3

Closed-Loop Validation

Launch adaptive regimens where the OS auto-modulates synthesis delivery based on real-time feedback loops.

Target KPIs

85% predictive accuracy
20% improvement in objective healthspan metrics (e.g., DNAm PhenoAge, VO2 Max)
PHASE_03

Systemic Optimization

Architecture for Continuity

Timeline

5–8 Years Cumulative (2031 – 2034)

Scaling the OS for long-term stability via network effects and institutional integration.

Strategic Rationale

Scaling to multi-decade protocols and insurance-grade partnerships typically follows 5+ years of real-world stability data.

Key Milestones

3.1

Continuity Blueprints

Develop long-range protocols targeting mitochondrial health and protein homeostasis (autophagy).

3.2

Network Effect Activation

Aggregate anonymized population data to enable 'Cohort Intelligence'—refining predictions for specific genetic profiles.

3.3

Institutional Grade Rollout

Secure partnerships with insurance providers to categorize Monument as a 'Disease Interception' infrastructure.

Target KPIs

100,000+ active managed biologies
90% of users maintaining markers within optimal ranges for 5+ years
PHASE_04

Biological Permanence

The Standard

Timeline

10+ Years (2034 and Beyond)

The ultimate realization of an autonomous, global infrastructure for human longevity.

Strategic Rationale

Aligning with the 10–15 year lifecycle for true 'Standard of Care' status in the global longevity market.

Key Milestones

4.1

Autonomous Maintenance

Background-integrated delivery (e.g., bio-implantables) that corrects biological drift with zero user friction.

4.2

Full-Spectrum OS Integration

Unified platform managing everything from molecular synthesis to cognitive/neuro-resilience.

4.3

Global Standard Setting

Collaboration with the WHO and FDA to establish Monument as the benchmark for 'Human Infrastructure.'

Target KPIs

95% intervention autonomy
25% projected extension of healthy lifespan across primary cohorts

Strategic Summary

A decade-long commitment to redefining human infrastructure.

01 Infrastructure

2029

Objective

Build the Base

Output

Precision Synthesis & OS v1.0

02 Intelligence

2031

Objective

Enable Foresight

Output

Predictive Foresight Engine

03 Continuity

2034

Objective

Ensure Stability

Output

Institutional-Grade Platform

04 Permanence

2036+

Objective

Define the Future

Output

Total Bio-Infrastructure